Publications

Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.

TGFBR2, TGFβ signaling, antisense oligonucleotide, drug development, therapeutic frontiers
Kuespert, S.; Heydn, R.; Peters, S.; Wirkert, E.; Meyer, A.-L.; Siebörger, M.; Johannesen, S.; Aigner, L.; Bogdahn, U.; Bruun, T.-H. Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling. International journal of molecular sciences 2020, 21, doi:10.3390/ijms21061952.

Value of fluid-attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis.

FLAIR, LST, amyotrophic lateral sclerosis
Wirth, A.M.; Johannesen, S.; Khomenko, A.; Baldaranov, D.; Bruun, T.-H.; Wendl, C.; Schuierer, G.; Greenlee, M.W.; Bogdahn, U. Value of fluid-attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis. Journal of magnetic resonance imaging : JMRI 2019, 50, 552-559, doi:10.1002/jmri.26577.

Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study.

Amyotrophic lateral sclerosis, ALS, cytokines, Granulocyte-colony stimulating factor, G-CSF, Hematopoietic stem and progenitor cells, HSPC, Telomere length
Iberl, S.; Meyer, A.-L.; Müller, G.; Peters, S.; Johannesen, S.; Kobor, I.; Beier, F.; Brümmendorf, T.; Hart, C.; Schelker, R.; et al. Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study. Cytokine 2019, 120, 192-201, doi:10.1016/j.cyto.2019.05.003.

Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

Beier, D.; Proescholdt, M.; Reinert, C.; Pietsch, T.; Jones, D.; Pfister, S.; Hattingen, E.; Seidel, C.; Dirven, L.; Luerding, R.; et al. Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro-oncology 2018, 20, 400-410, doi:10.1093/neuonc/nox155.

Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis.

ALSFRS-R, MUNIX, amyotrophic lateral sclerosis, cortical thickness, magnetic resonance imaging
Wirth, A.M.; Khomenko, A.; Baldaranov, D.; Kobor, I.; Hsam, O.; Grimm, T.; Johannesen, S.; Bruun, T.-H.; Schulte-Mattler, W.; Greenlee, M.W.; et al. Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis. Frontiers in neurology 2018, 9, 614, doi:10.3389/fneur.2018.00614.

Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients.

HSPC, amyotrophic lateral sclerosis, cytokines, granulocyte-colony stimulating factor, hematopoietic stem and progenitor cells, treatment
Johannesen, S.; Budeus, B.; Peters, S.; Iberl, S.; Meyer, A.-L.; Kammermaier, T.; Wirkert, E.; Bruun, T.-H.; Samara, V.C.; Schulte-Mattler, W.; et al. Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients. Frontiers in neurology 2018, 9, 971, doi:10.3389/fneur.2018.00971.

Educational attainment and motor burden in advanced Parkinson's disease - The emerging role of education in motor reserve.

Cognitive reserve, Deep brain stimulation, Education, Motor reserve, Parkinson, UPDRS
Blume, J.; Rothenfusser, E.; Schlaier, J.; Bogdahn, U.; Lange, M. Educational attainment and motor burden in advanced Parkinson's disease - The emerging role of education in motor reserve. Journal of the neurological sciences 2017, 381, 141-143, doi:10.1016/j.jns.2017.08.3241.

Intraoperative clinical testing overestimates the therapeutic window of the permanent DBS electrode in the subthalamic nucleus.

Deep brain stimulation, Intraoperative clinical testing, Microelectrode recording, Parkinson, Stimulation-induced side effects, Subthalamic nucleus
Blume, J.; Schlaier, J.; Rothenfußer, E.; Anthofer, J.; Zeman, F.; Brawanski, A.; Bogdahn, U.; Lange, M. Intraoperative clinical testing overestimates the therapeutic window of the permanent DBS electrode in the subthalamic nucleus. Acta neurochirurgica 2017, 159, 1721-1726, doi:10.1007/s00701-017-3255-4.

The impact of white matter lesions on the cognitive outcome of subthalamic nucleus deep brain stimulation in Parkinson's disease.

Cognition, Deep brain stimulation, Parkinson, Parkinson dementia, Subthalamic nucleus, White matter lesions
Blume, J.; Lange, M.; Rothenfusser, E.; Doenitz, C.; Bogdahn, U.; Brawanski, A.; Schlaier, J. The impact of white matter lesions on the cognitive outcome of subthalamic nucleus deep brain stimulation in Parkinson's disease. Clinical neurology and neurosurgery 2017, 159, 87-92, doi:10.1016/j.clineuro.2017.05.023.

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.

BTIC, STAT3, Stattic, glioma, metformin
Leidgens, V.; Proske, J.; Rauer, L.; Moeckel, S.; Renner, K.; Bogdahn, U.; Riemenschneider, M.; Proescholdt, M.; Vollmann-Zwerenz, A.; Hau, P.; et al. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget 2017, 8, 8250-8263, doi:10.18632/oncotarget.14159.

Metabolic syndrome in relation to risk of meningioma.

case-control study, epidemiology, meningioma, metabolic syndrome
Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Proescholdt, M.; Bogdahn, U.; Hau, P.; Leitzmann, M. Metabolic syndrome in relation to risk of meningioma. Oncotarget 2017, 8, 2284-2292, doi:10.18632/oncotarget.13667.

The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.

TGF-β, adult neurogenic niche, amyotrophic lateral sclerosis, fibrosis, immunity
Peters, S.; Zitzelsperger, E.; Kuespert, S.; Iberl, S.; Heydn, R.; Johannesen, S.; Petri, S.; Aigner, L.; Thal, D.R.; Hermann, A.; et al. The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis. Frontiers in neurology 2017, 8, 669, doi:10.3389/fneur.2017.00669.

Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis.

DTI metrics, diffusion tensor imaging, magnetic resonance imaging, neurodegeneration, neurodegenerative disease
Baldaranov, D.; Khomenko, A.; Kobor, I.; Bogdahn, U.; Gorges, M.; Kassubek, J.; Müller, H.-P. Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis. Frontiers in human neuroscience 2017, 11, 567, doi:10.3389/fnhum.2017.00567.

Statin use and risk of glioma: population-based case-control analysis.

Case–control study, epidemiology, glioma, Statins
Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Bogdahn, U.; Hau, P.; Leitzmann, M. Statin use and risk of glioma: population-based case-control analysis. European journal of epidemiology 2016, 31, 947-52, doi:10.1007/s10654-016-0145-7.

Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.

AMPK, BTIC, Smad, TGF-β2, glioblastoma, mTOR, metformin
Seliger, C.; Meyer, A.-L.; Renner, K.; Leidgens, V.; Moeckel, S.; Jachnik, B.; Dettmer, K.; Tischler, U.; Gerthofer, V.; Rauer, L.; et al. Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2. Cell cycle (Georgetown, Tex.) 2016, 15, 1755-66, doi:10.1080/15384101.2016.1186316.

CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.

PD-1, PD-L1, T effector memory cell, glioblastoma, myeloid-derived suppressor cell
Dubinski, D.; Wölfer, J.; Hasselblatt, M.; Schneider-Hohendorf, T.; Bogdahn, U.; Stummer, W.; Wiendl, H.; Grauer, O. CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients. Neuro-oncology 2016, 18, 807-18, doi:10.1093/neuonc/nov280.

Toward the validation of a new method (MUNIX) for motor unit number assessment.

amyotrophic lateral sclerosis, Incremental stimulation motor unit number estimation, Motor unit number estimation, Motor unit number index, Spike-triggered averaging motor unit number estimation
Stein, F.; Kobor, I.; Bogdahn, U.; Schulte-Mattler, W. Toward the validation of a new method (MUNIX) for motor unit number assessment. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology 2016, 27, 73-7, doi:10.1016/j.jelekin.2016.02.001.

Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study.

Kirzinger, L.; Boy, S.; Marienhagen, J.; Schuierer, G.; Neu, R.; Ried, M.; Hofmann, H.-S.; Wiebe, K.; Ströbel, P.; May, C.; et al. Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study. PloS one 2016, 11, e0168215, doi:10.1371/journal.pone.0168215.

Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro.

Moeckel, S.; Vollmann-Zwerenz, A.; Proescholdt, M.; Brawanski, A.; Riemenschneider, M.; Bogdahn, U.; Bosserhoff, A.-K.; Spang, R.; Hau, P. Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro. PloS one 2016, 11, e0151312, doi:10.1371/journal.pone.0151312.

Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma.

Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Bogdahn, U.; Hau, P.; Leitzmann, M. Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma. PloS one 2016, 11, e0149293, doi:10.1371/journal.pone.0149293.

Activation of TGF-β-induced non-Smad signaling pathways during Th17 differentiation.

Hasan, M.; Neumann, B.; Haupeltshofer, S.; Stahlke, S.; Fantini, M.; Angstwurm, K.; Bogdahn, U.; Kleiter, I. Activation of TGF-β-induced non-Smad signaling pathways during Th17 differentiation. Immunology and cell biology 2015, 93, 662-72, doi:10.1038/icb.2015.21.

Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts.

Kandasamy, M.; Rosskopf, M.; Wagner, K.; Klein, B.; Couillard-Despres, S.; Reitsamer, H.; Stephan, M.; Nguyen, H.; Riess, O.; Bogdahn, U.; et al. Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts. PloS one 2015, 10, e0116069, doi:10.1371/journal.pone.0116069.

Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.

Leidgens, V.; Seliger, C.; Jachnik, B.; Welz, T.; Leukel, P.; Vollmann-Zwerenz, A.; Bogdahn, U.; Kreutz, M.; Grauer, O.; Hau, P. Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. PloS one 2015, 10, e0140613, doi:10.1371/journal.pone.0140613.

The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity.

ALS, G-CSF, SCI, angiogenesis, arteriogenesis, neurogenesis, neuroregeneration, plasticity
Wallner, S.; Peters, S.; Pitzer, C.; Resch, H.; Bogdahn, U.; Schneider, A. The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity. Frontiers in cell and developmental biology 2015, 3, 48, doi:10.3389/fcell.2015.00048.

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis.

Aging, Neural stem cell, neurogenesis, Proliferation, Smad, TGF-beta signaling
Marschallinger, J.; Krampert, M.; Couillard-Despres, S.; Heuchel, R.; Bogdahn, U.; Aigner, L. Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Experimental gerontology 2014, 57, 149-54, doi:10.1016/j.exger.2014.05.011.

TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons.

Smad2, TGF-β1, cell cycle, differentiation, doublecortin, stem cells
Kandasamy, M.; Lehner, B.; Kraus, S.; Sander, P.; Marschallinger, J.; Rivera, F.; Trümbach, D.; Ueberham, U.; Reitsamer, H.; Strauss, O.; et al. TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. Journal of cellular and molecular medicine 2014, 18, 1444-59, doi:10.1111/jcmm.12298.

Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis.

ALS, amyotrophic lateral sclerosis, G-CSF, granulocyte-colony stimulating factor
Grassinger, J.; Khomenko, A.; Hart, C.; Baldaranov, D.; Johannesen, S.; Mueller, G.; Schelker, R.; Schulte-Mattler, W.; Andreesen, R.; Bogdahn, U. Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis. Cytokine 2014, 67, 21-8, doi:10.1016/j.cyto.2014.02.003.

Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro.

Seliger, C.; Leukel, P.; Moeckel, S.; Jachnik, B.; Lottaz, C.; Kreutz, M.; Brawanski, A.; Proescholdt, M.; Bogdahn, U.; Bosserhoff, A.-K.; et al. Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro. PloS one 2013, 8, e78935, doi:10.1371/journal.pone.0078935.

Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality.

action potential firing, adult neural progenitor cells, neuronal excitability, voltage-gated ion channels
Kraus, S.; Lehner, B.; Reichhart, N.; Couillard-Despres, S.; Wagner, K.; Bogdahn, U.; Aigner, L.; Strauß, O. Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality. Glia 2013, 61, 1767-83, doi:10.1002/glia.22551.

Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord.

Sandner, B.; Rivera, F.; Caioni, M.; Nicholson, L.S.; Eckstein, V.; Bogdahn, U.; Aigner, L.; Blesch, A.; Weidner, N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem cell research 2013, 11, 758-71, doi:10.1016/j.scr.2013.05.003.

Stem cell metabolic and spectroscopic profiling.

Sander, P.; Hau, P.; Koch, S.; Schütze, K.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. Stem cell metabolic and spectroscopic profiling. Trends in biotechnology 2013, 31, 204-13, doi:10.1016/j.tibtech.2013.01.008.

The cancer stem cell subtype determines immune infiltration of glioblastoma.

Beier, C.; Kumar, P.; Meyer, K.; Leukel, P.; Bruttel, V.; Aschenbrenner, I.; Riemenschneider, M.; Fragoulis, A.; Rümmele, P.; Lamszus, K.; et al. The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem cells and development 2012, 21, 2753-61, doi:10.1089/scd.2011.0660.

1H-nuclear magnetic resonance spectroscopy of glioblastoma cancer stem cells.

Ramm, P.; Bettscheider, M.; Beier, D.; Kalbitzer, H.; Kremer, W.; Bogdahn, U.; Hau, P.; Aigner, L.; Beier, C. 1H-nuclear magnetic resonance spectroscopy of glioblastoma cancer stem cells. Stem cells and development 2011, 20, 2189-95, doi:10.1089/scd.2010.0567.

TGF-β2 signaling in high-grade gliomas.

Hau, P.; Jachimczak, P.; Schlaier, J.; Bogdahn, U. TGF-β2 signaling in high-grade gliomas. Current pharmaceutical biotechnology 2011, 12, 2150-7.

Comprehensive small animal imaging strategies on a clinical 3 T dedicated head MR-scanner; adapted methods and sequence protocols in CNS pathologies.

Pillai, D.; Heidemann, R.; Kumar, P.; Shanbhag, N.; Lanz, T.; Dittmar, M.; Sandner, B.; Beier, C.; Weidner, N.; Greenlee, M.W.; et al. Comprehensive small animal imaging strategies on a clinical 3 T dedicated head MR-scanner; adapted methods and sequence protocols in CNS pathologies. PloS one 2011, 6, e16091, doi:10.1371/journal.pone.0016091.

Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease.

Kandasamy, M.; Reilmann, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease. Neurology research international 2011, 2011, 124256, doi:10.1155/2011/124256.

Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study.

Bogdahn, U.; Hau, P.; Stockhammer, G.; Venkataramana, N.; Mahapatra, A.; Suri, A.; Balasubramaniam, A.; Nair, S.; Oliushine, V.; Parfenov, V.; et al. Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro-oncology 2011, 13, 132-42, doi:10.1093/neuonc/noq142.

Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease.

Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.

Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner.

Krampert, M.; Chirasani, S.; Wachs, F.-P.; Aigner, R.; Bogdahn, U.; Yingling, J.; Heldin, C.-H.; Aigner, L.; Heuchel, R. Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner. Molecular and cellular biology 2010, 30, 3685-94, doi:10.1128/MCB.00434-09.

Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease.

Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.

Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis.

Kleiter, I.; Song, J.; Lukas, D.; Hasan, M.; Neumann, B.; Croxford, A.; Pedré, X.; Hövelmeyer, N.; Yogev, N.; Mildner, A.; et al. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain : a journal of neurology 2010, 133, 1067-81, doi:10.1093/brain/awq039.

Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides.

Hau, P.; Jachimczak, P.; Bogdahn, U. Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides. Expert review of anticancer therapy 2009, 9, 1663-74, doi:10.1586/era.09.138.

RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study.

Beier, C.; Schmid, C.; Gorlia, T.; Kleinletzenberger, C.; Beier, D.; Grauer, O.; Steinbrecher, A.; Hirschmann, B.; Brawanski, A.; Dietmaier, C.; et al. RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study. BMC cancer 2009, 9, 308, doi:10.1186/1471-2407-9-308.

Ageing abolishes the effects of fluoxetine on neurogenesis.

Couillard-Despres, S.; Wuertinger, C.; Kandasamy, M.; Caioni, M.; Stadler, K.; Aigner, R.; Bogdahn, U.; Aigner, L. Ageing abolishes the effects of fluoxetine on neurogenesis. Molecular psychiatry 2009, 14, 856-64, doi:10.1038/mp.2008.147.

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

Baumann, F.; Leukel, P.; Doerfelt, A.; Beier, C.; Dettmer, K.; Oefner, P.; Kastenberger, M.; Kreutz, M.; Nickl-Jockschat, T.; Bogdahn, U.; et al. Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro-oncology 2009, 11, 368-80, doi:10.1215/15228517-2008-106.

A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis?

Ramm, P.; Couillard-Despres, S.; Plötz, S.; Rivera, F.; Krampert, M.; Lehner, B.; Kremer, W.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis? Stem cells (Dayton, Ohio) 2009, 27, 420-3, doi:10.1634/stemcells.2008-0816.

Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures.

Rivera, F.; Siebzehnrubl, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Poehler, A.-M.; Berninger, B.; Sandner, B.; Bogdahn, U.; Goetz, M.; et al. Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009, 24, 317-24, doi:10.1159/000233256.

Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors.

Rivera, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Sanchez, R.; Huber, C.; Weidner, N.; Bogdahn, U.; Aigner, L. Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors. Journal of neurochemistry 2008, 107, 832-43, doi:10.1111/j.1471-4159.2008.05674.x.

CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors.

Beier, D.; Wischhusen, J.; Dietmaier, W.; Hau, P.; Proescholdt, M.; Brawanski, A.; Bogdahn, U.; Beier, C. CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors. Brain pathology (Zurich, Switzerland) 2008, 18, 370-7, doi:10.1111/j.1750-3639.2008.00130.x.

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.

Winner, B.; Rockenstein, E.; Lie, C.; Aigner, R.; Mante, M.; Bogdahn, U.; Couillard-Despres, S.; Masliah, E.; Winkler, J. Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiology of aging 2008, 29, 913-25.

Human in vitro reporter model of neuronal development and early differentiation processes.

Couillard-Despres, S.; Quehl, E.; Altendorfer, K.; Karl, C.; Ploetz, S.; Bogdahn, U.; Winkler, J.; Aigner, L. Human in vitro reporter model of neuronal development and early differentiation processes. BMC neuroscience 2008, 9, 31, doi:10.1186/1471-2202-9-31.

TGF-beta in neural stem cells and in tumors of the central nervous system.

Aigner, L.; Bogdahn, U. TGF-beta in neural stem cells and in tumors of the central nervous system. Cell and tissue research 2008, 331, 225-41.

Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult.

Hennemann, B.; Ickenstein, G.; Sauerbruch, S.; Luecke, K.; Haas, S.; Horn, M.; Andreesen, R.; Bogdahn, U.; Winkler, J. Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult. Cytotherapy 2008, 10, 303-11, doi:10.1080/14653240801949994.

Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis.

Kleiter, I.; Pedré, X.; Mueller, A.; Poeschl, P.; Couillard-Despres, S.; Spruss, T.; Bogdahn, U.; Giegerich, G.; Steinbrecher, A. Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis. Journal of neuroimmunology 2007, 187, 61-73.

Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies.

Hau, P.; Jachimczak, P.; Schlingensiepen, R.; Schulmeyer, F.; Jauch, T.; Steinbrecher, A.; Brawanski, A.; Proescholdt, M.; Schlaier, J.; Buchroithner, J.; et al. Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 2007, 17, 201-12.

Failure of Schwann cells as supporting cells for adult neural progenitor cell grafts in the acutely injured spinal cord.

Vroemen, M.; Caioni, M.; Bogdahn, U.; Weidner, N. Failure of Schwann cells as supporting cells for adult neural progenitor cell grafts in the acutely injured spinal cord. Cell and tissue research 2007, 327, 1-13.

Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells.

Rivera, F.; Couillard-Despres, S.; Pedré, X.; Ploetz, S.; Caioni, M.; Lois, C.; Bogdahn, U.; Aigner, L. Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem cells (Dayton, Ohio) 2006, 24, 2209-19.

Decrease of thalamic gray matter following limb amputation.

Draganski, B.; Moser, T.; Lummel, N.; Gänssbauer, S.; Bogdahn, U.; Haas, F.; May, A. Decrease of thalamic gray matter following limb amputation. NeuroImage 2006, 31, 951-7.

Transforming growth factor-beta1 is a negative modulator of adult neurogenesis.

Wachs, F.-P.; Winner, B.; Couillard-Despres, S.; Schiller, T.; Aigner, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming growth factor-beta1 is a negative modulator of adult neurogenesis. Journal of neuropathology and experimental neurology 2006, 65, 358-70.

In vivo high-resolution MR imaging of neuropathologic changes in the injured rat spinal cord.

Weber, T.; Vroemen, M.; Behr, V.; Neuberger, T.; Jakob, P.; Haase, A.; Schuierer, G.; Bogdahn, U.; Faber, C.; Weidner, N. In vivo high-resolution MR imaging of neuropathologic changes in the injured rat spinal cord. AJNR. American journal of neuroradiology 2006, 27, 598-604.

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

Stupp, R.; Mason, W.; van den Bent, M.; Weller, M.; Fisher, B.; Taphoorn, M.; Belanger, K.; Brandes, A.; Marosi, C.; Bogdahn, U.; et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England journal of medicine 2005, 352, 987-96.

Neuroplasticity: changes in grey matter induced by training.

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