Prof. Dr. Ludwig Aigner

Prof. Dr. Ludwig Aigner
Chief Scientific Officer

Coordinator of SCI-TReCS in Salzburg, with competencies in Neurogenesis, Stem Cell Regulation, Neurodegeneration & Drug Discovery, and >197 Publications & Patents

 

career

Since 2008 Director of the Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg
1999-2006 Clinical Neuroscience, University of Regensburg
1995-1998 Postdoc: McGill, Montreal

Publications

Ramm, P.; Couillard-Despres, S.; Plötz, S.; Rivera, F.; Krampert, M.; Lehner, B.; Kremer, W.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis? Stem cells (Dayton, Ohio) 2009, 27, 420-3, doi:10.1634/stemcells.2008-0816.
Marschallinger, J.; Krampert, M.; Couillard-Despres, S.; Heuchel, R.; Bogdahn, U.; Aigner, L. Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Experimental gerontology 2014, 57, 149-54, doi:10.1016/j.exger.2014.05.011.
Rivera, F.; Siebzehnrubl, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Poehler, A.-M.; Berninger, B.; Sandner, B.; Bogdahn, U.; Goetz, M.; et al. Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009, 24, 317-24, doi:10.1159/000233256.
Kandasamy, M.; Lehner, B.; Kraus, S.; Sander, P.; Marschallinger, J.; Rivera, F.; Trümbach, D.; Ueberham, U.; Reitsamer, H.; Strauss, O.; et al. TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. Journal of cellular and molecular medicine 2014, 18, 1444-59, doi:10.1111/jcmm.12298.
Rivera, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Sanchez, R.; Huber, C.; Weidner, N.; Bogdahn, U.; Aigner, L. Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors. Journal of neurochemistry 2008, 107, 832-43, doi:10.1111/j.1471-4159.2008.05674.x.
Kraus, S.; Lehner, B.; Reichhart, N.; Couillard-Despres, S.; Wagner, K.; Bogdahn, U.; Aigner, L.; Strauß, O. Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality. Glia 2013, 61, 1767-83, doi:10.1002/glia.22551.
Couillard-Despres, S.; Quehl, E.; Altendorfer, K.; Karl, C.; Ploetz, S.; Bogdahn, U.; Winkler, J.; Aigner, L. Human in vitro reporter model of neuronal development and early differentiation processes. BMC neuroscience 2008, 9, 31, doi:10.1186/1471-2202-9-31.
Sandner, B.; Rivera, F.; Caioni, M.; Nicholson, L.S.; Eckstein, V.; Bogdahn, U.; Aigner, L.; Blesch, A.; Weidner, N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem cell research 2013, 11, 758-71, doi:10.1016/j.scr.2013.05.003.
Aigner, L.; Bogdahn, U. TGF-beta in neural stem cells and in tumors of the central nervous system. Cell and tissue research 2008, 331, 225-41.
Sander, P.; Hau, P.; Koch, S.; Schütze, K.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. Stem cell metabolic and spectroscopic profiling. Trends in biotechnology 2013, 31, 204-13, doi:10.1016/j.tibtech.2013.01.008.
Rivera, F.; Couillard-Despres, S.; Pedré, X.; Ploetz, S.; Caioni, M.; Lois, C.; Bogdahn, U.; Aigner, L. Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem cells (Dayton, Ohio) 2006, 24, 2209-19.
Ramm, P.; Bettscheider, M.; Beier, D.; Kalbitzer, H.; Kremer, W.; Bogdahn, U.; Hau, P.; Aigner, L.; Beier, C. 1H-nuclear magnetic resonance spectroscopy of glioblastoma cancer stem cells. Stem cells and development 2011, 20, 2189-95, doi:10.1089/scd.2010.0567.
Wachs, F.-P.; Winner, B.; Couillard-Despres, S.; Schiller, T.; Aigner, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming growth factor-beta1 is a negative modulator of adult neurogenesis. Journal of neuropathology and experimental neurology 2006, 65, 358-70.
Kandasamy, M.; Reilmann, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease. Neurology research international 2011, 2011, 124256, doi:10.1155/2011/124256.
Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.
Kuespert, S.; Heydn, R.; Peters, S.; Wirkert, E.; Meyer, A.-L.; Siebörger, M.; Johannesen, S.; Aigner, L.; Bogdahn, U.; Bruun, T.-H. Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling. International journal of molecular sciences 2020, 21, doi:10.3390/ijms21061952.
Krampert, M.; Chirasani, S.; Wachs, F.-P.; Aigner, R.; Bogdahn, U.; Yingling, J.; Heldin, C.-H.; Aigner, L.; Heuchel, R. Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner. Molecular and cellular biology 2010, 30, 3685-94, doi:10.1128/MCB.00434-09.
Peters, S.; Zitzelsperger, E.; Kuespert, S.; Iberl, S.; Heydn, R.; Johannesen, S.; Petri, S.; Aigner, L.; Thal, D.R.; Hermann, A.; et al. The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis. Frontiers in neurology 2017, 8, 669, doi:10.3389/fneur.2017.00669.
Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.
Kandasamy, M.; Rosskopf, M.; Wagner, K.; Klein, B.; Couillard-Despres, S.; Reitsamer, H.; Stephan, M.; Nguyen, H.; Riess, O.; Bogdahn, U.; et al. Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts. PloS one 2015, 10, e0116069, doi:10.1371/journal.pone.0116069.

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